Quite often we'll have one or more nodes in any functional group of nodes where the inputs are being fed from nodes to the right and the output is going to nodes on the left. No amount of rearranging the nodes will avoid wires running right to left. Flipping the node about a vertical axis would put the input(s) on the right and output port(s) on the left.
If the redesign of Vuo results in nodes being asymmetric in the horizontal plane then flipped nodes would be more readily apparent than otherwise, and no additional visual cue would be required. If nodes frames are symmetrical, then a right to left arrow at top or bottom of node could be useful.
Here's an example of asymmetric node design, design appropriated from an old nord synth app.